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It is suspected that, to counteract possible increases in UV-induced DNA damage, a greater requirement for the nuclear localization of this multienzyme complex and the availability of 5,10-methyleneTHF substrate is needed in the case of high UV exposure

Microdosing or extended interval strategies may reduce medication usage, injection frequency, and side effect management costs

The use of fluorescence emission from a NIR-dye could be used to guide resection of tumour bulk, for example during endoscopic diagnosis for oesophago-gastric adenocarcinoma, this would then be followed by activation of the photodynamic therapeutic agent to destroy untreated localised areas of cancer infiltration and tumour infiltrated lymph nodes

J Clin Invest 1993

A standardized data extraction form specifically created for this purpose was utilised to gather pertinent data