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In HCC, gut microbiota dysbiosis inhibits the cGAS-STING-IFN-I pathway, impairing the antigen presentation function of dendritic cells and weakening the activation and function of effector CD8 + T cells, leading to primary resistance to radiotherapy or ICI

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By combining the PEI/CpG/OVA nano-vaccine with HAase, the infiltration of antigen-specific CD8 + T cells generated by the vaccine in tumor tissues has significantly enhanced the efficacy of in vivo anti-tumor immunotherapy

Subsequently, lipid peroxyl radicals further interact with fatty acids leading to the production of either lipid radicals or lipid hydroperoxides

It typically affects the legs and feet, but it can affect any part of your body, leading to pain, numbness, and sometimes loss of function