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Ethics statement The studies involving humans were approved by the Ethics Committee of Ospedali Riuniti Villa SofiaCervello (n

10.1158/0008-5472.CAN-10-0145 61 FrancoO

In this respect, CaP treatments could influence the composition of the ligand milieu, which may further impact on AR conformations and action as ligand represents the third determinant of NR allostery [77]