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(5) Patients with significant alcohol consumption, defined as more than 20 g/day for women or 30 g/day for men, or a history of alcohol-related liver disease [18]

It is generally recommended to start with a dose of 500 mg per day and gradually increase it if necessary

ALA diminishes the production of ROS, facilitates Nrf2 nuclear translocation, and enhances the expression of downstream antioxidant defenses, thus mitigating damage induced by oxidative stress