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Ardura-Fabregat A, Boddeke EW, Boza-Serrano A, Brioschi S, Castro-Gomez S, et al

10.1097/00004647-199905000-00003 J

As of right now, the benefits are unsubstantiated

Clinical trials combining these agents reported 35-40% discontinuation rates when both were dosed together

As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells