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Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping

Its transport to mitochondria results in cell apoptosis via mitochondrial transmembrane potential (m) dissipation, cytochrome c release, and Bcl-2 - associated X protein (Bax) activation [93]