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This finding indicated a profound impairment of ATP production, reflected by decreases in the OCR-linked ATP levels ( Figures 2A, C )

However, at this point dietary non-heme iron is in the ferric form, so it has to be reduced by the ferric reductase, cytochrome b reductase 1 (CYBRD1) prior to its absorption ( Two major destinations for TF-bound iron leaving the small intestine are the liver and bone marrow (Xiao et al., 2020