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It has been proposed that depletion of hepatic GSH, particularly mitochondrial GSH, is one of the early changes associated with chronic alcohol consumption and is a critical contributor to ALD pathogenesis 11

Most therapeutic interventions remain in preclinical development, with clinical translation hindered by two key barriers: The lack of validated biomarkers for patient stratification and incomplete elucidation of synergistic combination mechanisms

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Multivariate analysis showed that male (hazard ratio [HR] 2.27, 95%CI 1.17-4.39, P=0.013), platelet count 8.3x10 4 /l (HR 2.11, 95%CI 1.06-4.19, P=0.032) and presence of EV before BRTO (HR 2.36, 95%CI 1.06-5.27, P=0.029) were significant independent risk factors of EV worsening