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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

Breakthroughs are urgently needed to overcome the low specificity and side effects of metabolic therapy

An overdose is very unlikely if you consume this compound exclusively from whole foods

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