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This accumulation results in mitochondrial dysfunction, an elevation in ROS, and structural changes due to macromolecular cross-linking

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Asgarpanah J

Despite the antitumor effect of erastin, evidence has also shown that iron concentration and macrophage polarization in the tumor microenvironment promote the resistance of ovarian cancer cells to erastin-induced ferroptosis

However, aberrant glycosylation can also modify antigen processing and MHC loading, giving rise to glycopeptide neoantigens that are capable of engaging T-cell receptors (TCRs) in a distinct manner