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Binding of PHF3, DIDO, and RBM15 to Pol II was abrogated upon loss of the SPOC domain, indicating that the SPOCCTD interaction is of critical importance in establishing their interaction with Pol II (Fig

A.PartridgeL.SerranoM.KroemerG

In a statement, the ECHA noted that SEAC acknowledges the need for targeted derogations for specific PFAS uses when this is justified by the available evidence that alternatives are not available as well as by the assessment of costs and benefits, to ensure the restriction remains proportionate. A final decision from SEAC is expected by end-2026