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doi: 10.1172/JCI115286

113 In the canonical Wnt/-catenin pathway, the protein destruction complex (adenomatous polyposis coli [APC], casein kinase 1 [CK1], glycogen synthase kinase 3 [GSK-3], and axis inhibition proteins [AXINs]) targets and phosphorylates the -catenin protein

and eicosanoids (e.g., prostaglandins and leukotrienes) that are derived from arachidonic acid

Here, we constructed a transomic network of glucose metabolism by integrating western blotting, transcriptomic, and metabolomics data of the mouse liver following multiple doses of glucose administration

The agency noted that it approved 46 novel drugs and biologics last year, including 43% that were first-in-class, and half that were for rare or orphan diseases