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This is primarily achieved through two key enzymes: Methionine synthase (MS), a vitamin B12-dependent enzyme, catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (a derivative of folate) to homocysteine, regenerating methionine.Alternatively, in liver and kidney cells, betaine-homocysteine methyltransferase (BHMT) can also catalyze this remethylation reaction, using betaine as the methyl donor

BJU Int 88 : 6367 Cavallini G et al

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Wang, C., Cui, J.-J., Sheng, T., Xia, S., Li, J.-M., & Zhang, B.-F

The following acylcarnitines were nominally associated with major depression: palmitoylcarnitine, decanoylcarnitine, stearoylcarnitine, cis-4-decenoyl carnitine, 2-tetradecenoyl carnitine, and oleoylcarnitine (Supplementary Table S5)