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Stable-isotope tracers including [U- 13 C]-glucose, [U- 13 C]-glutamine, [U- 13 C]-acetate, [U- 13 C]-serine, [U- 13 C]-cysteine, [U- 13 C]-glycine, and [U- 13 C]-pyruvate were purchased from Cambridge Isotope Laboratories (MA, USA)

On examination, well-demarcated areas of pigmentation localized to knuckles of both hands were noticed (Figure 1)

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The procedure typically involves an intravenous infusion of a chelating agent, the most common of which is Ethylenediaminetetraacetic acid (EDTA)