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The repair deficiency may partly relate to a diabetes-associated downregulation of BRCA1/2 function in breast tumors, as our data suggest, and to metabolic alterations that increase oxidative stress and reduce the availability of -ketoglutarate

[DOI] [PubMed] [Google Scholar] 369.Ursini F

Lowering the encapsulation efficiency of hydrophilic drugs in liposomes primarily results from the hydrophobic nature of the liposome bilayer, which limits the entrapment of these drugs [39, 40]