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Although limited information exists on the exact mechanisms, recent studies suggest passive diffusion as the primary mechanism for cellular uptake of natural curcumin, including clathrin-mediated endocytosis ( At low concentrations, curcumin primarily interacts with the polar heads of the outer membrane surface

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A mutation in Zip7 has been identified as the cause of an autosomal recessive disorder, which is characterized by the lack of B cells and immunoglobulins, resulting in early-onset infections [44]

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