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Prefrontal and frontal cortices are pivotal components of the pain matrix and of the fronto-limbic, frontostriatal, and default-mode networks that regulate pain perception, emotionally driven behaviors, and attention allocation (Li et al., 2018

A quantitative comparison of NIRS and fMRI across multiple cognitive tasks

Goodman, A

In the connection to metabolism, boosting mitochondrial metabolism of LAC rapidly regulates central and peripheral insulin resistance (IR) [67], which is metabolic dysfunction implicated in the pathophysiology of both MDD and AD [68]