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A BMD 100 CI overlap does not necessarily mean that the comet assay response for compounds is the same but indicates that the BMD analysis cannot distinguish between them (Slob 2014

Loss-of-function GSTM2 mouse model demonstrated that GSTM2 protected mice from excess fat accumulation

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This state of oxidative and nitrosative stress is a hallmark of numerous neurodegenerative diseases, underscoring the central role of astrocytic redox regulation in maintaining CNS homeostasis and preventing neuropathology

The dose may then be increased to 60 mg or 80 mg twice daily on the second day of treatment and subsequently adjusted on the basis of tolerance and efficacy within the range 40 mg to 80 mg twice daily