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doi: 10.1186/s12931-020-01507-9 96 KimG-DLimEYShinHS

By understanding the biological characteristics of the cells to be killed, different types of ligands/molecules, such as peptides (186), antibodies (187, 188), proteins (189), polysaccharides (190), nucleic acids (191) and receptors (192), can be attached to the surface of the carrier or be applied to directly target to PC tissue (193), fibroblasts (194), KRAS mutant cells (195), tumourassociated macrophages (196), the tumour microenvironment (197), or nerves amongst PC cells (198) to increase the ratio of target to nontarget delivery