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IGFBP-2 is the second most abundant binding protein in adult serum and is often elevated in catabolic states and in certain cancers, where it has attracted study as a biomarker

Neurosci Lett 204(3):201204

Self-assembly mechanism of a bimetallic europium triple-stranded helicate

2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation (Tan and Song, 2023),these damages further lead to mitochondrial dysfunction, which in turn prompts more ROS production, forming a positive feedback loop (Tan and Vlajkovic, 2023)