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Levels of action of antioxidants The antioxidants molecules that constitute the antioxidant defense grid in living systems act at different levels

Curr Opin Immunol 48:6873

When OPG dominates, bone formation gets the upper hand

GBM-derived EVs can remodel the TME, making it more conducive to tumor growth and immune evasion through the delivery of specific signaling molecules ( In vivo , defects in exosome synthesis and downregulation of CD73 expression significantly suppressed GBM tumor growth and restored the clonal proliferation of T cells in central and peripheral regions ( Overall, GBM cells form a multilayered ferroptosis resistance network through EV-mediated iron efflux, antioxidant signaling transfer, and immune regulation

These beneficial effects are achieved by down-regulating the phosphorylation of NF-B p65 and mitogen-activated protein kinase (MAPK) pathways (37)