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Aldehydes originating from lipids exhibit high reactivity, leading them to readily engage with proteins to create Michael adducts, commonly referred to as advanced lipoxidation end products (ALEs) [Frijhoff et al ., 2015]

Factors such as hypoxia, nutrient deprivation, and the presence of stromal cells can influence drug efficacy and contribute to the development of resistance mechanisms (Ma et al., 2024[81])

A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis

NGF, neuron growth factor