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In the retina, Mller cells perform essential functions for the maintenance of homeostasis, many of which are related to their metabolism, so that energy restriction due to oxidative stress and mitochondrial dysfunction may contribute to the pathogenesis of glaucoma and the loss of RGCs (Kawasaki et al., 2000

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Moreover, dendritic spines that receive most excitatory synaptic inputs have been shown to contain no mitochondria (Kasthuri et al., 2015), despite being sites of intense energy utilization

The eumelanin within melanosomes shields cells from further UVR damage by absorbing, reflecting and refracting light

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