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The Benoist 2014 study used the HGF/MET dimerization antagonist Hinge to demonstrate that blocking c-Met activation eliminates Dihexas procognitive effect in scopolamine-impaired rats

Kamrul-Hasan ABM, Dutta D, Nagendra L, Bhattacharya S, Singla R, Kalra S

Ehrenreich, H

Numerous clinical trials using rh-HGF protein or targeting HGF genes for clinical treatment are ongoing, which indicates that HGF may be a promising target for the therapies of human diseases

A peptide may look promising in a lab dish or animal model, but clinical usefulness depends on whether the compound reaches the right tissue, stays stable long enough, and produces a meaningful benefit in real patients