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Disorders affecting heme synthesis, the globin genes, iron acquisition of erythroid precursors, or iron availability prevent adequate hemoglobinization and maturation of RBC cytoplasm, resulting in hypochromic microcytic cells

CrossRef KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure Ju-hong Jang, Jeong Woong Lee, Min Ji Cho, Byungtae Hwang, Min-Gi Kwon, Dong-Hwan Kim, Nam-Kyung Lee, Jangwook Lee, Young-Jun Park, Yong Ryoul Yang, Jinchul Kim, Yong-Hoon Kim, Tae Hyeon An, Kyoung-Jin Oh, Kwang-Hee Bae, Jong-Gil Park, Jeong-Ki Min Experimental & Molecular Medicine.2022

The discrepancy between the two studies may be attributed to the different molecular mechanisms related to models, as the STZ-induced diabetic model employed by Xie et al

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