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In summary, our discovery of the isoxazole Acs inhibitors and the structural and biochemical characterization of their mechanism of inhibition provides novel insights that should be useful to the design of Acs inhibitors for both infectious disease indications as well as the treatment of human cancers and metabolic diseases

When using RNA-seq technology based on techniques to observe the signal cascade reactions related to RGC death in retinal IR injury, it was found that the level of the Steap3 gene responsible for encoding the production of Fe 2+ and Fe 3+ was more than twice as high as that in the normal group

Combination and sequential therapies based on ROS tuning This section operationalizes ROS therapy as a time-staged sequence rather than a single intervention

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