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Evidence suggests their presence indicates a distinct condition, or at least a more-clearly delineated subtype of IC/BPS

doi: 10.1021/tx4003116

Finally, nitrogen concentration was determined by UHPLCMS, using the Ultimate 3,000 system (ThermoScientific, United States)

Anti-drug antibody formation has been found to be an increased risk in males without any endogenous enzyme (139), higher levels of lyso-GB3 (140, 142, 143) and in some literature the use of agalsidase beta, suggesting there is a link to the increased dosage of agalsidase beta compared to agalsidase alpha (144)

The association was primarily present and became stronger among participants who did not meet the estimated average requirement (EAR) level of Mg intake for all-cause mortality (HR, 3.22