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Oncotarget 2016;7:8010910

Wirth EK, Conrad M, Winterer J, Wozny C, Carlson BA, Roth S, et al

Safety considerations (hypercalcemia/mineral imbalance) apply to active agents and high-dose bolus regimens

GSH deficiency on hepatocyte epigenetic modifying enzymes Hepatocytes treated with GCLC siRNA showed elevated Dnmt, Tet2, and Tet3, but Tet1 was downregulated, and there was no change in Tdg mRNA expression (Fig