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A previous report highlighted that leukotrienes exert their activities by binding to 2 distinct GPCR subfamilies, namely BLT and CysLT receptors

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Furthermore, prolotherapy (dextrose prolotherapy) requires a high level of clinical skill and vigilance to ensure accurate assessment, which may affect the consistency and reliability of outcome measurements across studies and must take into consideration specific etiological subtypes to better identify which patients are most likely to benefit from this intervention