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These results established cagrilintide as a clinically meaningful agent in its own right, while also confirming that its mechanism was distinct enough from existing therapies to warrant combination investigation

Cristiano C, Lama A, Lembo F, Mollica MP, Calignano A, Mattace RG

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Each pellet was then resuspended in 150 l GS lysis buffer (150 mM KCl, 5 mM MgCl2, 50 mM Tris 7.4, 0.5% NP-40, and 0.5 mM DTT [all reagents were at RNA grade]), freshly supplemented with protease inhibitors cocktail (539134-1ML