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We noticed a rise in TXNIP and a fall in TXNRD1 for responders in the anti-PD1-treated CT26 mouse model

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

10.1124/jpet.102.047092 203 ShinJ

Pharmacological characterization To examine whether the potent weight loss observed in vivo after GLP-1MK-801 treatment is attributable to pharmacological synergy between GLP-1 and MK-801 or consequential to altered pharmacokinetic properties of the parent GLP-1 analogue, we designed and synthesized a conjugate comprising an inactive MK-801 surrogate 22 (Supplementary Fig