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The effects were attributed to decreased BBB permeability, suppression of pro-inflammatory cytokines (TNF-a and IL-6), and modulation of excitatory and inhibitory neurotransmitter signalling [151]

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In cases where a chronic condition is causing a deficiency, people may require B12 shots around every month

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FIGURE 4 We next explored the relationship between vitamin B12 protection and ER stress by using 4-PBA, which is the most commonly used ER stress inhibitor