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By modulating the harmful effects of senescence, these therapies could slow down or even reverse conditions such as neurodegenerative diseases (eg, Alzheimers, Parkinsons), cardiovascular disease, arthritis, and metabolic disorders (eg, type 2 diabetes).193 Since many of these diseases are associated with the accumulation of senescent cells and their inflammatory secretions, senomorphic compounds have the potential to treat the root cause of these diseases, rather than just alleviating symptoms.201 Personalized Medicine Approaches: As our understanding of individual aging profiles and senescence mechanisms deepens, there is an opportunity to design personalized treatments based on a persons genetic makeup, lifestyle factors, and specific senescence-related conditions

It is widely known that ROS is a critical marker of oxidative damage as it can disrupt nuclear and cell membranes and mediate NET production 28

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Selective Agonism Rather than activating receptors fully, some experimental medications partially activate them or activate specific subtypes

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