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doi: 10.1007/s12010-022-04190-2 56 Al SharifMTsakovskaIAlovPVitchevaVDiukendjievaAPajevaI

Because mitochondria produce a lot of free radicals as a byproduct of making energy, they need a high concentration of glutathione nearby to prevent damage

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This allows for the passage of germs, endotoxins, and other toxic chemicals into the bloodstream, which can induce a systemic inflammatory response and further worsen BBB failure (Gu et al., 2021)