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Compared to patients with MASLD or MetALD, patients with ALD were significantly younger (mean age 55.1y vs

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Aspartate aminotransferase (AST), a major hepatocellular transaminase, participates in amino acid catabolism and synthesis and serves as an indicator of amino acid metabolism (30, 31)

Oxidative cellular dysfunction is caused by highly reactive substances (such as hydrogen peroxide, superoxide, peroxynitrite and hydroxyl radicals) through a variety of mechanisms, such as lipid peroxidation, enzyme inactivation, mitochondrial respiratory chain failure, DNA alteration and/or cell death

This constitutes the core reason for the divergent conclusions across the different studies (Figure 3A)