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Reducing intestinal barrier permeability attenuates arthritis Since our results suggested that increased zonulin levels along with impaired intestinal permeability for lactulose and FITC-Dextran (FD4) are preceding the onset of murine and human arthritis, we sought an intervention that strengthens the intestinal barrier and may disrupt the transition from autoimmunity to inflammation and thereby inhibit the onset of arthritis

Leung PS, Lee YS, Tang CY, Kung WY, Chuang YH, Chiang BL et al (2008) Induction of shrimp tropomyosin-specific hypersensitivity in mice

Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation

If excessive cells die in tissues, serious Cardio-Cerebrovascular Diseases would occur, namely, hypertension, myocardial infarction, and ischemic stroke