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Evaluation and management of deficiency of adenosine deaminase 2: an international consensus statement

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Environmental factors, which vary significantly between African and Western populations, also contribute to differences in treatment response

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Besides, the ability of PA to establish drug resistant biofilms is thought to be facilitated by the hypersecretion of the thick and viscous mucus layer in the CF airway, which provides a low oxygen environment (Moreau-Marquis et al., 2008)