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Supplementation Under the guidance of a doctor, many parents find success with: Methylated B Vitamins: Specifically L-methylfolate and methylcobalamin (B12)

Advances in pharmaceutical technology

MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24

however, this was not replicated in adult Down syndrome mice (Giacomini et al., 2019)

But as one of the accompanying editorials noted, a hazard ratio of 4.5 is quite large, and its hard to attribute entirely to residual confounding when the researchers already controlled for the primary cardiovascular risk factors