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HPA Axis Regulation: DSIP influences the hypothalamic-pituitary-adrenal (HPA) axis, altering cortisol release patterns and helping to manage stress hormone levels

This broad pleiotropy was supported by associations observed in the 23andMe database (Supplementary Table 19)

Finally, PEFs promoted an abscopal effect clearing lung metastases, with the effect being stronger when combined with anti-PD-1 therapy than PEFs alone (82)

Animal studies have reported the presence of GLP-1R mRNA in the glomerulus and the initial part of proximal convoluted tubes (190)

As well as helping modulate inflammation, there is some evidence that the peptide can have activity against certain microbes