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Interestingly, the FRD- and proinflammatory cytokine-induced dysregulation of genes encoding islet markers was reversed after NMN treatment

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While the employed rodent model replicates key metabolic and histopathological features of the human condition, and the conservation of the identified target pathways between species supports the biological plausibility of our findings, several critical aspects remain to be fully addressed

In such a case, the payment limit based on the ASPs of competitor biosimilars would be higher than if we were constrained to use ASP data only from the biosimilar that has most recently reported negative or zero manufacturer's ASP data

They are not necessarily better or worse, just different tools for different aspects of the problem