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Oral administration may deliver lower systemic levels but provides direct contact with the gastrointestinal tract

plasma ester concentrations peak within several days and then decline with an apparent half-life of approximately eight days, yielding biologically active estradiol levels that can persist for three to four weeks after a single injection

They are related but not identical

[DOI] [PubMed] [Google Scholar] 59.Wang Y, Wen X, Hao D, et al

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