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The functional differences and potential heterotachy in these homologous genes dictate caution when evaluating their timing and evolutionary order

Mesial temporal lobe epilepsy (MTLE), often accompanied by hippocampal sclerosis (HS), is characterized by severe neuronal loss and glial proliferation in the hippocampus (229, 230)

The RNA sequence and gene set enrichment analysis revealed the downregulation of the type I interferon (IFN-I) pathway in MPTP-induced mice, which was then counteracted by the overexpression of miR-218-5p

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They also proposed that aspartame may contribute to oxidative stress and the release of cortisol