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doi: 10.1007/s00784-003-0208-5

However, sustained high doses, overdose, fasting, alcohol use, or pre-existing liver disease can overwhelm glutathione reserves, increasing risk of hepatotoxicity and oxidative stress

Gustavsson P

1-3 HyperHEP B contains high titers of antibodies, equivalent to or exceeding the potency of anti-HBs in a US reference hepatitis B immune globulin standard (established by the Center for Biologics Evaluation and Research, FDA), and provides rapid immune protection for postexposure prophylaxis (PEP)

Most people notice visible changes between weeks 6 and 12, though the timeline depends on starting weight, dose, and individual physiology