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doi: 10.26508/lsa.202302011 31 ChowdhuryM

Konopleva M, Estrov Z, Zhao S, Andreeff M , Mehta K

Discovery of a new eugenol-benznidazole hybrid active against different evolutive stages of Trypanosoma cruzi

264,265 Both PMOs and PNAs are neutral nucleic acid analogs with weak binding to plasma proteins, allowing them to be easily cleared by the kidneys

aeruginosa strains have more 8-oxoGua upon exposure to polymorphonucleates (PMN) and this mechanism is proposed to be linked to an increased antibiotic resistance