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RT-qPCR analysis revealed that key metabolic genes, including gnd , PxpA , HBL79_RS05810 , HBL79_RS03605 , and EIIB were significantly downregulated, consistent with our transcriptomic results (Figures 4AF)

To compare the differences in labeling intensity between FITC-HNG and FITC-SHLP3, the explants were imaged with the same acquisition parameters and fluorescence intensity profiles of HNG and SHLP3 were generated

DNA Repair (Amst.) 12 , 620636 (2013)

10.1074/jbc.M112.402677 70 ParpuraV.BasarskyT

However, there have been indications that regular doses of 1 g over extended periods, such as months or years, may reduce bactericidal activity in leukocytes and increase the risk of stone formation caused by temporary urate excretion elevation