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Results ROXY9 adopts a thioredoxin fold similar to Arabidopsis GRXC2 Class III GRX ROXY9 (AT2G47880) and class I GRXC2 (AT5G40370) from A

NADPH oxidase 4 (NOX4), a ROS-producing enzyme, is highly expressed in the livers of NASH patients and contributes to pathological inflammation and fibrosis in a mouse model of diet-induced NASH (94)

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Crossing these Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice produced Jnk hepa ( Jnk hepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity