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Erdosteine reduces the exercise-induced oxidative stress in patients with severe COPD: results of a placebo-controlled trial

Later experiments have found that adding high doses of copper can increase reactive oxygen species and protein carbonylation levels, decrease glutathione levels and SOD enzyme activity, leading to depolarization of mitochondrial membrane potential, the release of cytochrome c, elevated levels of active caspase-9 and caspase-3, increased levels of Bcl2-antagonist/killer 1 (Bak1) and Bcl2-associated X protein (Bax), and decreased levels of B-cell lymphoma 2 (Bcl2), ultimately resulting in cell apoptosis (134)

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In additional, our controls were not given a placebo

10.1016/j.transci.2023.103755 78 RinalducciS.FerruE.BlasiB.TurriniF.ZollaL