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Hypoxia is a significant angiogenic stimulus, as vascular smooth muscle cells proliferate and produce hypoxia-inducible factor-1 (HIF-1) in large quantities under hypoxic conditions

Adrenarche also still occurs (except in those children with pituitary and subsequent adrenal failure), but development of secondary sex characteristics does not follow

doi: 10.1016/j.jep.2022.115264 106 KassimMAchouiMMustafaMRMohdMAYusoffKM

This reduction lifts the inhibition on autophagy and triggers autophagosome formation, as evidenced by increased levels of LC3-II/I and Beclin-1, alongside a decrease in p62