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When valproate-treated adult rats are examined for PKC phosphorylation of substrates NMDAR1 and MARCKS, there is a significant decrease in immunoblotting tests of phosphorylation by pkc, indicating a downregulation of hippocampal pkc activity due to valproate (Watson et al., 1998)

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Twitching eyes can also be caused by neurological disorders such as epilepsy, multiple sclerosis, and cerebral palsy

Traditional Chinese medicine and its bioactive components can help prevent and manage these conditions by restoring the integrity of the intestinal mucosal barrier