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RPMI, penicillin, streptomycin and FBS were purchased from Gibco Life Technologies (Grand Island, NY, USA)

To achieve equivalent systemic exposure, oral protocols typically use 100150mg doses to compensate for the reduced absorption

Conversely, NRF2 induces the transcription of downstream genes such as HMOX1 and NQO1, neutralizing ROS and thereby alleviating necroptosis-mediated tissue injury [135]